scholarly journals Spindle cell tumors resected from male patients with germ cell tumors. A clinicopathologic study of 14 cases

Cancer ◽  
1990 ◽  
Vol 65 (1) ◽  
pp. 148-156 ◽  
Author(s):  
Thomas M. Ulbright ◽  
Helen Michael ◽  
Patrick J. Loehrer ◽  
John P. Donohue
Keyword(s):  
Germ Cell ◽  
Spindle Cell ◽  
Germ Cell Tumors ◽  
Clinicopathologic Study ◽  
Male Patients ◽  
Spindle Cell Tumors

Advanced Germ Cell Tumors in Male Patients

2000 ◽  
Vol 93 (11) ◽  
pp. 1054-1066 ◽  
Author(s):  
ZEINA NAHLEH ◽  
JORGE GALLARDO ◽  
IMAD A. TABBARA
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Male Patients

Etoposide, Methotrexate, and Dactinomycin Alternating With Cyclophosphamide and Vincristine (EMACO) for Male Patients With HCG-expressing, Chemoresistant Germ Cell Tumors

2017 ◽  
Vol 40 (1) ◽  
pp. 60-65 ◽  
Author(s):  
Daniele Raggi ◽  
Patrizia Giannatempo ◽  
Rosalba Miceli ◽  
Elena Farè ◽  
Luigi Piva ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Male Patients

Intensive Induction Chemotherapy With CBOP/BEP in Patients With Poor Prognosis Germ Cell Tumors

2003 ◽  
Vol 21 (5) ◽  
pp. 871-877 ◽  
Author(s):  
J.A. Christian ◽  
R.A. Huddart ◽  
A. Norman ◽  
M. Mason ◽  
S. Fossa ◽  
...  
Keyword(s):  
Germ Cell ◽  
Induction Chemotherapy ◽  
Poor Prognosis ◽  
Germ Cell Tumors ◽  
Phase Iii ◽  
Royal Marsden Hospital ◽  
Prognosis Group ◽  
Male Patients ◽  
Patients With Poor Prognosis

Purpose: Despite a high cure rate in patients with testicular cancer, there remain patients in the poor prognosis group who have a less favorable outcome. Intensive induction chemotherapy using a regimen consisting of carboplatin, bleomycin, vincristine, and cisplatin, followed by bleomycin, etoposide, and cisplatin (CBOP/BEP), developed at the Royal Marsden Hospital, is designed to overcome the rapid proliferation seen in germ cell tumors. This study assesses the outcome of patients with poor-prognosis nonseminomatous germ cell tumors (NSGCT) treated with CBOP/BEP. Patients and Methods: Patients with NSGCT from three centers, classified as poor prognosis according to International Germ Cell Classification Consensus Group criteria, were treated with CBOP/BEP regimen during the period from 1989 to 2000. Data on treatment toxicity, relapse-free survival (RFS), and overall survival (OS) were collected prospectively on a hospital database. Results: Fifty-four male patients with poor prognosis NSGCT were treated with CBOP/BEP. The RFS at 3 and 5 years for all patients was 83.2% (95% confidence interval [CI], 68.8% to 91.3%). After a median follow-up of 4 years, the OS of the 54 patients was 91.5% (95% CI, 78.6% to 96.8%) at 3 years and 87.6% (95% CI, 71.3% to 94.9%) at 5 years. Three-year OS in patients with a primary mediastinal germ cell tumor was 77.1% (95% CI, 34.5% to 93.9%) compared with 95.4% (95% CI, 82.8% to 98.8%) in patients with a testicular primary tumor (P = .24). Conclusion: The results reported here compare favorably with the historical results of alternative regimens used in the management of poor-prognosis NSGCT. We suggest a phase III trial to confirm our findings.

Imaging of Metastatic Germ Cell Tumors in Male Patients From Initial Diagnosis to Treatment-Related Toxicities: A Primer for Radiologists

2020 ◽  
Vol 214 (1) ◽  
pp. 24-33
Author(s):  
Monica J. Wood ◽  
Richard Thomas ◽  
Stephanie A. Howard ◽  
Marta Braschi-Amirfarzan
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Initial Diagnosis ◽  
Male Patients

Outcomes of male patients with germ cell tumors and bone metastases: A mono-institutional retrospective study.

2018 ◽  
Vol 36 (6_suppl) ◽  
pp. 570-570
Author(s):  
Guillaume Moriceau ◽  
Helen Jane Boyle ◽  
Nathalie Bonnin ◽  
Christophe Sajous ◽  
Patrice Peyrat ◽  
...  
Keyword(s):  
Germ Cell ◽  
Bone Metastases ◽  
Bone Disease ◽  
Germ Cell Tumors ◽  
Progression Free Survival ◽  
Initial Diagnosis ◽  
Bone Surgery ◽  
Male Patients ◽  
Metastatic Sites

570 Background: Bone metastases (BM) are considered as intermediate or poor prognosis according to the international classification of Germ Cell Tumors (GCT). The present study compares the outcomes between patients with bone disease at initial diagnosis and bone disease at relapse and between seminoma and non-seminoma GCT. Methods: We investigated retrospectively all male-patients presenting GCT with BM at initial diagnosis or at relapse, between 2005 and 2015, in a single institution. Results: Thirty-nine patients were included. Median age was 36 (from 20 to 67). Nineteen patients presented with BM at initial diagnosis (49%) and 20 patients presented BM at relapse (51%). Histologically, 13 patients (33%) presented a seminoma and 26 patients (67%) a non-seminoma GCT. Twenty-four patients (62%) had multiples bone metastatic sites. Vertebra was the most frequent location (70%). Bone surgery was performed for five patients with seminoma (38%) and four patients with non-seminoma GCT (15%). Median overall survival (OS) was 130.9 months for the 19 patients with BM at initial diagnosis and 15.2 months for the 20 patient with BM at relapse HR 5.3 95%CI[1.75;16.06], p < 0.001. Median progression free survival (PFS) was 120.10 months for patients with BM at initial diagnosis and 9.21 months for patients with BM at relapse, HR 3.02 95%CI[1.16;7.83], p < 0.0016. Survivals are longer for patients with seminoma than patients with non-seminoma GCT. Median PFS was 9.41 months for the 13 patient with non-seminoma GCT and not achieved for the 26 patients with seminoma, HR 0.15, 95%CI [0.003;0.65], p 0.001 . Median OS was 18.7 months for the 13 patient with non-seminoma GCT and not achieved for the 26 patients with seminoma, HR 0.16 95% CI [0.004;0.7], p 0.002. Conclusions: BM of GCT are associated with a worse prognosis especially for non-seminoma subtype and/or when BM arise at relapse. This data highlights the importance of the first line therapeutic strategy as the corner stone of treatment for patients with GCT.

Seminoma presented with acute abdomen due to ileum perforation

Open Medicine ◽  
2010 ◽  
Vol 5 (5) ◽  
pp. 636-639
Author(s):  
Ali Filiz ◽  
İlker Sücüllü ◽  
Yavuz Kurt ◽  
Oğuz Okul ◽  
Zafer Küçükodaci ◽  
...  
Keyword(s):  
Germ Cell ◽  
Acute Abdomen ◽  
Germ Cell Tumors ◽  
Exploratory Laparotomy ◽  
Right Hemicolectomy ◽  
Pathological Examination ◽  
Hollow Viscus ◽  
Palpable Mass ◽  
Ileal Perforation ◽  
Male Patients

AbstractGerm cell tumors presenting with an acute abdomen are not common. We present a case of seminoma with ileum perforation, which presented in a 48-year-old man. who had been admitted to hospital with a right lower abdominal palpable mass measuring approximately 16 cm. Before an exploratory laparotomy was performed, acute abdomen with signs of hollow viscus perforation had occurred. An ileum perforation was detected and a right hemicolectomy and ileal resection were performed. The pathological examination showed a classic seminoma of undescended testis. In conclusion, this case is interesting with respect to its clinical picture of acute abdomen due to ileal perforation. The possibility of a germ cell tumor should always be kept in mind in male patients with acute abdomen.

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